Leading rusher Ryan Mathews, the Chargers’ leading rusher, is out with a calf injury and has been designated as inactive.
That leaves the San Diego running game in the hands of Mike Tolbert, who missed practice time during the week with a hamstring injury.
Inactive for the Raiders are quarterback Terrelle Pryor, quarterback Jason Campbell, running backs Darren McFadden and Taiwan Jones, tackle/guard Bruce Campbell, tackle John Henderson and defensive end Mason Brodine.
Other San Diego inactives include wide receiver Bryan Walters, guard/tackle Tony Moll, outside linebacker Everette Brown, linebacker Nate Triplett and outside linebacker Travis LaBoy.