1. Union Square and Powell Street and Market is the hub of San Francisco shopping. They got a giant mall and any store you could ever ask for.
2. Go see a Giants Game, tis the season.
3. Pier 39 for Alcatraz and all kinds of touristy stuff
4. I know this is gonna sound retarded, but rent one of those little yellow go-carts and explore the city that way. I grew up in SF and still did it and it was one of the funnest things ive ever done in my life. $120 well spent, but make sure u make a reservation first.
5. Hit up the North Beach/Broadway district. Lots of cool italian restaurants, and broadway is strip club central and a few decent bars/clubs at night. Plus Chinatown is right next to it.
6. If you want nightlife as a tourist stick to Broadway, if you want other clubs you can go to Suite 181 (bring your shank), NV, and Temple. SF nightlife kind of sucks to be honest. I would hit a strip club.
If you want to grab a little SF latino culture hit up the Mission District but if you're mexican watch your colors, that red and blue shit will get you shot.
Just ask a cab driver where all these places are, you'll be good.
Have fun. Rap stations are 106.1 and 94.9 if you need some theme music at ur hotel or car.