out of boredom!
Chlamydia (bacterium)
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Chlamydia trachomatis
C. trachomatis inclusion bodies (brown) in a McCoy cell culture.
Scientific classificationKingdom:
Bacteria
Phylum:
Chlamydiae
Order:
Chlamydiales
Family:
Chlamydiaceae
Genus:
Chlamydia
Species
Chlamydia muridarum
Chlamydia suis
Chlamydia trachomatis
For the disease in humans, see
Chlamydia infection.
Chlamydia is a
genus of
bacteria, several of which are
pathogenic.
[1] Notably,
chlamydia infections are the most common bacterial
sexually transmitted diseases in humans, as well as the leading cause of infectious blindness worldwide.
[1] Chlamydia are unusual bacteria: obligate intracellular organisms, they must infect host cells to mature and reproduce.
The three
Chlamydia species include
Chlamydia trachomatis (a human pathogen),
Chlamydia suis (affects only
swine), and
Chlamydia muridarum (affects only
mice and
hamsters).
[2] Prior to 1999, the
Chlamydia genus also included the species that are presently in the genus
Chlamydophila: Two clinically relevant species,
Chlamydophila pneumoniae and
Chlamydophila psittaci were moved to the
Chlamydophila genus.
[edit] Physiology
Chlamydia are unusual bacteria - unusual enough that they were originally classified as
protozoans (and then as
viruses), before
16S ribosomal RNA analysis placed them as members of the Eubacteria
domain.
[3] Chlamydia are
obligate intracellular parasite bacterial pathogens, and are thus unable to replicate outside of a host cell. However, to disseminate effectively, these pathogens have evolved a unique biphasic life cycle wherein they alternate between two functionally and morphologically distinct forms:
[4]
- The elementary body (EB) is infectious, but metabolically inert (much like a spore), and can survive for limited amounts of time in the extracellular milieu. Once the EB attaches to a susceptible host cell, it mediates its own internalization through pathogen-specified mechanisms (via type III secretion system) that allows for the recruitment of actin with subsequent engulfment of the bacterium.[5]
- The internalized EB, within a membrane-bound compartment, immediately begins differentiation into the reticulate body (RB). RBs are metabolically active but non-infectious, and in many regards, resemble normal replicating bacteria.[6] The intracellular bacteria rapidly modifies its membrane-bound compartment into the so-called chlamydial inclusion so as to prevent phagosome-lysosome fusion. According to published data, the inclusion has no interactions with the endocytic pathway and apparently inserts itself into the exocytic pathway as it retains the ability to intercept sphingomyelin-containing vesicles.
To date, no one has been able to detect a host cell protein that is trafficked to the inclusion through the exocytic pathway. As the RBs replicate, the inclusion grows as well to accommodate the increasing numbers of organisms. Through unknown mechanisms, RBs begin a differentiation program back to the infectious EBs, which are released from the host cell to initiate a new round of infection. Because of their obligate intracellular nature,
Chlamydia have no tractable genetic system, unlike
E. coli, which makes
Chlamydia and related organisms difficult to investigate.
^^that shit is like...sigourney weaver on aliens
peace to not having cell-destroying parasites