Not real familiar with downtown Phoenix cause i stay more on the east
side of the valley but if you ever make it out to the Tempe/Scottsdale area where I think it's poppin the most in the valley these are the spots...
Thurdays....Tempe is the place to be...Acme on Rural Rd, Dos Gringos just down the street...The Library on Mill Ave is always crackin...lil small though, mostly a bar night, clubs are hoppin but not like the rest of the weekend
Friday....(see Saturday clubs) You can easily spend more then a weekend going to those 3 spots and still not see all there is to offer, but Saturdays def the night to hit them up...as for Friday I say hit up Skin, Jenna Jameson's club / strip club...some of the finest tail you will ever see up in that bitch
Saturday....Head up to Scottsdale...theres 3 clubs (Myst, Axis Radius, Suede) all own by the same guy all right next to each other with all kinds of bitches gettin down
Sunday....Pussy Cat Lounge in Scottsdale HANDS DOWN....Sundays are my fav night of the week cause of this spot...celebs are frequent and get this place flooding wit peeps gettin wild