Cloned dog celebrates first birthday

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Y-S

Sicc OG
Dec 10, 2005
3,765
0
0
#1
Daymn lol

SEOUL, South Korea (Reuters) -- The world's first and only cloned dog celebrated its first birthday on Monday, as the leader of the South Korean team that produced the Afghan hound faced a criminal investigation for possible fraud and ethics violations.

The team led by scientist Hwang Woo-Suk unveiled the dog named Snuppy last August amid global fanfare. Time magazine named Snuppy one of the most amazing inventions for 2005.

Hwang once basked in acclaim for his scientific achievements, with some in the country labeling him "the pride of Korea".

By the end of last year, however, his reputation was in tatters amid charges his team deliberately manipulated data and violated ethical standards in human egg procurement.

Hwang has since lost his professorship at Seoul National University and the case has been described by scientific experts as one of the biggest scientific frauds in recent history.

The birthday celebrations at the university where Hwang once ran his lab were subdued. Snuppy, short for Seoul National University puppy, is in good health and weighs about 29 kilograms (64 pounds), university officials said.

For his birthday, Snuppy enjoyed two of his favorite foods; ice cream and sausages.

In January, an investigation panel at the university said Hwang's team fabricated key data in two studies once hailed as landmark works on cloning human embryonic stem cells.

The panel said Snuppy was an actual clone.

Soon after the report, South Korean prosecutors started a criminal investigation into Hwang and his team.

Hwang has maintained he is a victim of a conspiracy to discredit him. He has not been available for comment for months.

"This makes us remember that Hwang had a successful career and was on the cutting edge of the science before the scandal broke," David Winickoff, an assistant professor of bioethics at the University of California Berkeley, said by telephone.

Even without Hwang, the lab at Seoul National University is continuing with its research into cloning technology.

"The government has agreed to support us and promised us significant funding," Professor Kim Min-Kyu said by telephone.

Dogs are considered one of the most difficult animals to clone because of their reproductive cycle. Snuppy was born after a normal pregnancy in a yellow Labrador surrogate mother.

The process was difficult and costly. A total of 1,095 reconstructed embryos were transferred into 123 surrogates to create two living puppies. The other cloned dog died after 22 days from pneumonia.

Both puppies were created from an adult skin cell taken from a male Afghan hound, using the same technique that was used to create Dolly, the world's first cloned sheep.

The Afghan was chosen because of its striking looks, remaining members of Hwang's team said. The process, they said, was far too costly and inefficient to be used to clone pet dogs.





That's like hacking the matrix or something
 
Mar 9, 2005
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#3
cute dog - I love how time magazine labelled him as one of the most amazing 'inventions' for 2005. However, I'm not sure about the authenticity of this cloning. Hwang Woo-Suk has botched a great deal of his results which brings it into question, but the numbers they provide seem about right.

Cloned animals have a lot of trouble for one main reason. Mitochondria are the power house of the cell, and they spend their whole lives generating reactive oxygen species (a by product of respiration, the means of energy production). These reactive oxygen species damage the mitochondria, reducing the efficiency of energy production and decreasing the integrity of the mitochondrial membrane and DNA.

In normal reproduction, mitochondria are passed on from mother to child. Those mitochondria found in Oocytes (eggs) are dormant, not undergoing any respiration and therefore not accumulating any damage. Thus, when children who are conceived in the natural way are born, their mitochondria are 'brand new' and are thus undamaged.

When an animal is cloned, the nucleus may be 'brand new' but the mitochondria in the recipient cell is aged and damaged. When this clone is 'born', it doesn't have a fresh start because it already has damaged mitochondria, resulting in decreased respiration rate and higher accumulation of mutations, which can lead to a variety of diseases. Therefore, this young animal can and most often does display diseases which are usually only found in aged counterparts. Their life expectancy is reduced before they're even born.

This doesn't happen every time - if you can successfully transfer a nucleus (without any mitochondria) into a de-nucleated Oocyte (nuclear transfer, the method in which Dolly the sheep was produced), you may be able to prevent this. It's damn tough though and I don't think anyone has been able to fully purge the nucleus of it's native mitochondria.

I'm sorry to have bored you, but there you go.
 

Y-S

Sicc OG
Dec 10, 2005
3,765
0
0
#4
well said, hutch - none boredom there

what if this cloned dog has a replaced mitochondria, though? what if he has a new mitochondria? I mean, scientists that created this dog should know what mitochondria is and what happens if is damaged, infected, etc, right? So...
 
May 8, 2002
1,763
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#5
Hutch said:
cute dog - I love how time magazine labelled him as one of the most amazing 'inventions' for 2005. However, I'm not sure about the authenticity of this cloning. Hwang Woo-Suk has botched a great deal of his results which brings it into question, but the numbers they provide seem about right.

Cloned animals have a lot of trouble for one main reason. Mitochondria are the power house of the cell, and they spend their whole lives generating reactive oxygen species (a by product of respiration, the means of energy production). These reactive oxygen species damage the mitochondria, reducing the efficiency of energy production and decreasing the integrity of the mitochondrial membrane and DNA.

In normal reproduction, mitochondria are passed on from mother to child. Those mitochondria found in Oocytes (eggs) are dormant, not undergoing any respiration and therefore not accumulating any damage. Thus, when children who are conceived in the natural way are born, their mitochondria are 'brand new' and are thus undamaged.

When an animal is cloned, the nucleus may be 'brand new' but the mitochondria in the recipient cell is aged and damaged. When this clone is 'born', it doesn't have a fresh start because it already has damaged mitochondria, resulting in decreased respiration rate and higher accumulation of mutations, which can lead to a variety of diseases. Therefore, this young animal can and most often does display diseases which are usually only found in aged counterparts. Their life expectancy is reduced before they're even born.

This doesn't happen every time - if you can successfully transfer a nucleus (without any mitochondria) into a de-nucleated Oocyte (nuclear transfer, the method in which Dolly the sheep was produced), you may be able to prevent this. It's damn tough though and I don't think anyone has been able to fully purge the nucleus of it's native mitochondria.
QUOTE]



Good shit.