^maschine has Midi out that you can route reason midi channels to trigger and playback in reason sounds in maschines sequencer. It might be tight for live use but then you would probably encounter issues trying to utilize the audio, it would have to be exported somehow. Havn't really messed with it yet kinda seems like a bitch. I mainly use maschine for sampled beats and drag and drop the audio and or Midi into my DAW Logic for access to better synth and keyboard sounds, FX etc. I guess you can use the midi out to set up patterns and stuff within maschine then use the drag and drop midi into the DAW back to the same channels and bus the data into audio tracks.
IMO reason isn't any more difficult to use than any other DAW or other beat making hardware or software, everything has a learning curve. You might have to open a book but if you spent a grand on an MPC id figure youd do the same thing. Its like going to school without reading the book or taking notes, you might get by but you won't really learn anything without applying yourself. Reason is a beast though, I've been using it for like 8 years and there is still shit i don't now about it.